Breakthrough AI Tool Predicts Liver Cancer Recurrence with 82% Accuracy
A new AI-powered tool developed by Singaporean scientists can predict liver cancer recurrence with over 82% accuracy. Discover how it works and how doctors can access it for free through a web portal.

A Game-Changer in Liver Cancer Care
In a remarkable step forward for cancer treatment, scientists in Singapore have developed an advanced AI tool that can predict liver cancer recurrence with an accuracy of 82.4% significantly improving early detection and personalized care strategies.
The tool, called TIMES (Tumour Microenvironment Spatial), was created by a research team at A*STAR’s Institute of Molecular and Cell Biology (IMCB) in collaboration with Singapore General Hospital (SGH). What makes it even more impactful? It’s now available for free online use through a research-based web portal.
How TIMES Works: AI Meets Precision Medicine
Unlike traditional methods that rely solely on tumor size or stage, TIMES dives deeper. It uses machine learning (specifically, an XGBoost model) to analyze how certain immune cells and gene expressions are spatially distributed within a tumor. The key focus is on natural killer (NK) cells and five genes, including the standout biomarker SPON2, which play crucial roles in cancer progression.
This high-tech analysis helps identify whether a liver cancer patient is at high risk of recurrence after surgical removal of the tumor — a major concern for up to 70% of patients who relapse within five years.
Why This Matters for Doctors and Patients
The TIMES tool can offer oncologists a more precise and personalized way to monitor patients post-surgery. By identifying who is most at risk for recurrence, doctors can plan closer follow-ups, early interventions, and even explore targeted therapies.
Its accuracy outperforms current clinical staging systems like the Barcelona Clinic Liver Cancer (BCLC) system, which often lacks the ability to predict outcomes at an individual level.
Free Online Portal Now Live
In a bold move toward global accessibility, the research team has made the TIMES platform available via a free web portal. Clinicians and researchers can upload tumor images to receive AI-generated risk assessments in just a few clicks. While it’s currently available for research use, validation studies are underway to integrate it into everyday hospital practice.
Plans are also in motion to convert the TIMES system into a diagnostic kit for routine clinical use in Singapore and beyond.
Global Recognition & What’s Next
This innovation has gained recognition from the global scientific community, including a feature in Nature, one of the world’s leading scientific journals. With additional trials set to take place at SGH and the National Cancer Centre Singapore, researchers are confident this tool could become a standard part of liver cancer management in the near future.
Conclusion: AI Is Reshaping the Future of Cancer Treatment
The TIMES AI tool is more than just a technological breakthrough it’s a life-saving innovation. By accurately predicting the likelihood of liver cancer returning after surgery, it empowers doctors and patients to make informed decisions and stay one step ahead of this aggressive disease.
And with the tool being freely accessible online, it marks a powerful step toward democratizing healthcare through AI.
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